Microbial proteins have recently been found to have more benefits in clinical disease treatment because of their better-developed strategy and properties than traditional medicine. In this study, we investigated the effectiveness of a truncated peptide synthesized from the C-terminal sequence of pneumolysin, i.e., C70PLY4, in Streptococcus pneumoniae, in treating chronic inflammatory conditions.
It has been shown that C70PLY4 significantly blocks the transendothelial migration of neutrophils and attenuates the formation of atherosclerotic plaque and the secretion of soluble forms of the intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in high-fat-diet/streptozotocin-induced inflammatory rats.
The mechanism and the docking simulation analysis further indicated that C70PLY4 might serve as a Toll–like receptor 4 (TLR4) antagonist by competing for the binding site of MD2, an indispensable protein for lipopolysaccharide (LPS)-TLR4 interaction signaling, on the TLR4 structure. Moreover, compared to the full-length PLY, C70PLY4 seems to have no cytotoxicity in human vascular endothelial cells.
Mouse SKT shRNA Plasmid |
20-abx980555 |
Abbexa |
|
|
|
96-Well Cell Culture Plates Flat Bottom Wells, TC Treated, 100 Plates/Unit |
25-109 |
Genesee Scientific |
100 plates |
EUR 200 |
Description: - Striation free, completely flat bases for even and consistent cell growth
- Optically clear with low autofluorescence for distortion free microscopy
- Low evaporation lid reduces evaporation and prevents contamination
- Well dimensions allow the use of specific tissue culture inserts
- Lot number printed on each individual plate
- Alphanumeric well coding for easy well identification
- Certified RNase & DNase-Free, Non-Pyrogenic & Non-Cytotoxic
- Sterilized by Gamma Irradiation to a Sterility Assurance Level of 10^-6
|
CD84 Recombinant Protein |
96-109 |
ProSci |
0.1 mg |
EUR 490.25 |
Description: Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contains one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor functioning by homophilic interactions and by clustering. CD84 / SLAMF5 increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. |
Mouse Sickle tail protein (SKT) ELISA Kit |
abx389166-96tests |
Abbexa |
96 tests |
EUR 911 |
|
Glucose Nutrient Mix |
109 |
AthenaES |
150 g |
EUR 67 |
YL-109 |
B4857-10 |
ApexBio |
10 mg |
EUR 463 |
YL-109 |
B4857-5 |
ApexBio |
5 mg |
EUR 325 |
YL-109 |
B4857-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 282 |
XMD17-109 |
A3942-100 |
ApexBio |
100 mg |
EUR 860 |
Description: XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 ?M, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 ?M. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells. |
XMD17-109 |
A3942-25 |
ApexBio |
25 mg |
EUR 438 |
Description: XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 ?M, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 ?M. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells. |
XMD17-109 |
A3942-5 |
ApexBio |
5 mg |
EUR 171 |
Description: XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 ?M, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 ?M. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells. |
XMD17-109 |
A3942-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 279 |
Description: XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 ?M, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 ?M. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells. |
Human Sickle tail protein homolog, SKT ELISA KIT |
ELI-18163h |
Lifescience Market |
96 Tests |
EUR 824 |
Mouse Cluster Of Differentiation 109 ELISA kit |
E03C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Mouse Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Cluster Of Differentiation 109 ELISA kit |
E08C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Canine Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Cluster Of Differentiation 109 ELISA kit |
E02C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rat Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Cluster Of Differentiation 109 ELISA kit |
E04C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Cluster Of Differentiation 109 ELISA kit |
E07C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Porcine Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Cluster Of Differentiation 109 ELISA kit |
E06C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Goat Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Cluster Of Differentiation 109 ELISA kit |
E01C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Human Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Cluster Of Differentiation 109 ELISA kit |
E09C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Monkey Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
EC-109 cells |
C0013001 |
Addexbio |
One Frozen vial |
EUR 777 |
hCRP FRET 96 |
CH1021-96 |
Mediomics |
1 Kit |
EUR 455 |
hCRP TRF 96 |
CHTR1021-96 |
Mediomics |
1 Kit |
EUR 482 |
hAlbumin FRET 96 |
AH1005-96 |
Mediomics |
1 Kit |
EUR 455 |
hAlbumin TRF 96 |
AHTR1005-96 |
Mediomics |
1 Kit |
EUR 482 |
hInsulin FRET 96 |
IH1017-96 |
Mediomics |
1 Kit |
EUR 455 |
hInsulin TRF 96 |
IHTR1017-96 |
Mediomics |
1 Kit |
EUR 482 |
rIgG FRET 96 |
RI1024-96 |
Mediomics |
1 Kit |
EUR 455 |
mIgG TRF 96 |
MIGTR1020-96 |
Mediomics |
1 Kit |
EUR 482 |
Guinea pig Cluster Of Differentiation 109 ELISA kit |
E05C0311-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit |
EF014796 |
Lifescience Market |
96 Tests |
EUR 689 |
CD20(109-3C2) Antibody |
BNCA0355-250 |
Biotium |
250uL |
EUR 383 |
Description: Primary antibody against CD20(109-3C2), APC conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNCAP0355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNCAP0355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC810355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF680R conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC810355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF680R conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC880355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF488A conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC880355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF488A conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNCB0355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), Biotin conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNCB0355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), Biotin conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC550355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF555 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC550355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF555 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC430355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF543 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC430355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF543 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC470355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF647 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC470355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF647 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC940355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF594 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC940355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF594 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNCP0355-250 |
Biotium |
250uL |
EUR 383 |
Description: Primary antibody against CD20(109-3C2), PerCP conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC040355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF405S conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC040355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF405S conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC050355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF405M conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC050355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF405M conjugate, Concentration: 0.1mg/mL |
IL13 109 a.a. Protein |
20-abx262191 |
Abbexa |
-
EUR 328.00
-
EUR 5826.00
-
EUR 230.00
|
|
|
CD20(109-3C2) Antibody |
BNCR0355-250 |
Biotium |
250uL |
EUR 383 |
Description: Primary antibody against CD20(109-3C2), RPE conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNUB0355-100 |
Biotium |
100uL |
EUR 209 |
Description: Primary antibody against CD20(109-3C2), Concentration: 0.2mg/mL |
CD20(109-3C2) Antibody |
BNUB0355-500 |
Biotium |
500uL |
EUR 458 |
Description: Primary antibody against CD20(109-3C2), Concentration: 0.2mg/mL |
CD20(109-3C2) Antibody |
BNC680355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF568 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC680355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF568 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC700355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF770 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC700355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF770 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC800355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF680 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC800355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF680 conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC400355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF640R conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC400355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF640R conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC610355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), CF660R conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNC610355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), CF660R conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNCH0355-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD20(109-3C2), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNCH0355-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD20(109-3C2), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
CD20(109-3C2) Antibody |
BNUM0355-50 |
Biotium |
50uL |
EUR 395 |
Description: Primary antibody against CD20(109-3C2), 1mg/mL |
HIST1H1C (Ab-109) Antibody |
1-CSB-PA010378OA109nforHU |
Cusabio |
|
|
|
Description: A polyclonal antibody against HIST1H1C (Ab-109). Recognizes HIST1H1C (Ab-109) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
HSC70 ELISA Kit |
SKT-106-96 |
Stressmarq |
1 plate of 96 wells |
EUR 717 |
|
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian |
HSP90 alpha ELISA Kit |
SKT-107-96 |
Stressmarq |
1 plate of 96 wells |
EUR 685 |
|
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian |
HSP70 ELISA Kit (High-Sensitivity) |
SKT-108-96 |
Stressmarq |
1 plate of 96 wells |
EUR 685 |
|
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse |
HSP60 ELISA Kit |
SKT-110-96 |
Stressmarq |
1 plate of 96 wells |
EUR 585 |
|
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human |
HO-1 ELISA Kit |
SKT-111-96 |
Stressmarq |
1 plate of 96 wells |
EUR 585 |
|
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat |
HSP65 ELISA Kit |
SKT-113-96 |
Stressmarq |
1 plate of 96 wells |
EUR 633 |
|
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum |
Alpha B Crystallin ELISA Kit |
SKT-123-96 |
Stressmarq |
1 plate of 96 wells |
EUR 717 |
|
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human |
HSP70 ELISA Kit (PLANT) |
SKT-124-96 |
Stressmarq |
1 plate of 96 wells |
EUR 717 |
|
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human |
Nitrotyrosine ELISA Kit |
SKT-126-96 |
Stressmarq |
1 plate of 96 wells |
EUR 460 |
|
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species |
Rat GRP78 ELISA Kit |
SKT-137-96 |
Stressmarq |
1 plate of 96 wells |
EUR 632 |
|
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat |
Dibromo-tyrosine ELISA Kit |
SKT-140-96 |
Stressmarq |
1 plate of 96 wells |
EUR 566 |
|
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species |
Cortisol EIA Kit |
SKT-201-96 |
Stressmarq |
1 plate of 96 wells |
EUR 329 |
|
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species |
Glutathione Detection Kit |
SKT-202-96 |
Stressmarq |
1 plate of 96 wells |
EUR 428 |
|
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species |
Glutathione S-Transferase Activity Kit |
SKT-203-96 |
Stressmarq |
1 plate of 96 wells |
EUR 428 |
|
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish |
Glutathione Reductase Activity Kit |
SKT-204-96 |
Stressmarq |
1 plate of 96 wells |
EUR 428 |
|
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human |
Corticosterone EIA Kit |
SKT-205-96 |
Stressmarq |
1 plate of 96 wells |
EUR 355 |
|
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species |
Cortisone CLIA Kit |
SKT-206-96 |
Stressmarq |
1 plate of 96 wells |
EUR 467 |
|
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species |
Prostaglandin E2 EIA Kit |
SKT-207-96 |
Stressmarq |
1 plate of 96 wells |
EUR 527 |
|
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species |
Cyclic AMP CLIA Kit (High-Sensitivity) |
SKT-208-96 |
Stressmarq |
1 plate of 96 wells |
EUR 494 |
|
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species |
Our study elucidated a possible therapeutic efficacy of C70PLY4 in reducing chronic inflammatory conditions and clarified the underlying mechanism. Thus, our findings identify a new drug candidate that, by blocking TLR4 activity, could be an effective treatment for patients with chronic inflammatory diseases.