Truncated Pneumolysin from Streptococcus pneumoniae as a TLR4-Antagonizing New Drug for Chronic Inflammatory Conditions.

Microbial proteins have recently been found to have more benefits in clinical disease treatment because of their better-developed strategy and properties than traditional medicine. In this study, we investigated the effectiveness of a truncated peptide synthesized from the C-terminal sequence of pneumolysin, i.e., C70PLY4, in Streptococcus pneumoniae, in treating chronic inflammatory conditions.
It has been shown that C70PLY4 significantly blocks the transendothelial migration of neutrophils and attenuates the formation of atherosclerotic plaque and the secretion of soluble forms of the intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in high-fat-diet/streptozotocin-induced inflammatory rats.
The mechanism and the docking simulation analysis further indicated that C70PLY4 might serve as a Tolllike receptor 4 (TLR4) antagonist by competing for the binding site of MD2, an indispensable protein for lipopolysaccharide (LPS)-TLR4 interaction signaling, on the TLR4 structure. Moreover, compared to the full-length PLY, C70PLY4 seems to have no cytotoxicity in human vascular endothelial cells.

Mouse SKT shRNA Plasmid

20-abx980555
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

96-Well Cell Culture Plates Flat Bottom Wells, TC Treated, 100 Plates/Unit

25-109 100 plates
EUR 200
Description:
  • Striation free, completely flat bases for even and consistent cell growth
  • Optically clear with low autofluorescence for distortion free microscopy
  • Low evaporation lid reduces evaporation and prevents contamination
  • Well dimensions allow the use of specific tissue culture inserts
  • Lot number printed on each individual plate
  • Alphanumeric well coding for easy well identification
  • Certified RNase & DNase-Free, Non-Pyrogenic & Non-Cytotoxic
  • Sterilized by Gamma Irradiation to a Sterility Assurance Level of 10^-6

CD84 Recombinant Protein

96-109 0.1 mg
EUR 490.25
Description: Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contains one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor functioning by homophilic interactions and by clustering. CD84 / SLAMF5 increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway.

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 911

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96 Tests
EUR 865

Glucose Nutrient Mix

109 150 g
EUR 67

XMD17-109

HY-15665 10mM/1mL
EUR 321

YL-109

HY-18619 50mg
EUR 383

YL-109

B4857-10 10 mg
EUR 463

YL-109

B4857-5 5 mg
EUR 325

YL-109

B4857-5.1 10 mM (in 1mL DMSO)
EUR 282

XMD17-109

A3942-100 100 mg
EUR 860
Description: XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 ?M, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 ?M. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells.

XMD17-109

A3942-25 25 mg
EUR 438
Description: XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 ?M, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 ?M. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells.

XMD17-109

A3942-5 5 mg
EUR 171
Description: XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 ?M, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 ?M. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells.

XMD17-109

A3942-5.1 10 mM (in 1mL DMSO)
EUR 279
Description: XMD17-109 is a new inhibitor of ERK5, IC50 value in HeLa cell is 0.09 ± 0.03 ?M, and in vitro, Enzymatic IC50 value is 0.162 ± 0.006 ?M. XMD17-109 is capable of inhibiting the ERK5 autophosphorylation in cells.

XMD17-109

B1685-25
EUR 800

XMD17-109

B1685-5
EUR 240

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96 Tests
EUR 824

Mouse Cluster Of Differentiation 109 ELISA kit

E03C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Cluster Of Differentiation 109 ELISA kit

E08C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Cluster Of Differentiation 109 ELISA kit

E02C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Cluster Of Differentiation 109 ELISA kit

E04C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Cluster Of Differentiation 109 ELISA kit

E07C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Cluster Of Differentiation 109 ELISA kit

E06C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Cluster Of Differentiation 109 ELISA kit

E01C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Cluster Of Differentiation 109 ELISA kit

E09C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

EC-109 cells

C0013001 One Frozen vial
EUR 777

hCRP FRET 96

CH1021-96 1 Kit
EUR 455

hCRP TRF 96

CHTR1021-96 1 Kit
EUR 482

hAlbumin FRET 96

AH1005-96 1 Kit
EUR 455

hAlbumin TRF 96

AHTR1005-96 1 Kit
EUR 482

hInsulin FRET 96

IH1017-96 1 Kit
EUR 455

hInsulin TRF 96

IHTR1017-96 1 Kit
EUR 482

rIgG FRET 96

RI1024-96 1 Kit
EUR 455

mIgG TRF 96

MIGTR1020-96 1 Kit
EUR 482

Guinea pig Cluster Of Differentiation 109 ELISA kit

E05C0311-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Cluster Of Differentiation 109 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit

EF014796 96 Tests
EUR 689

CD20(109-3C2) Antibody

BNCA0355-250 250uL
EUR 383
Description: Primary antibody against CD20(109-3C2), APC conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNCAP0355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNCAP0355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC810355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF680R conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC810355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF680R conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC880355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF488A conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC880355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF488A conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNCB0355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), Biotin conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNCB0355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), Biotin conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC550355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF555 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC550355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF555 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC430355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF543 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC430355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF543 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC470355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF647 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC470355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF647 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC940355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF594 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC940355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF594 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNCP0355-250 250uL
EUR 383
Description: Primary antibody against CD20(109-3C2), PerCP conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC040355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF405S conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC040355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF405S conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC050355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF405M conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC050355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF405M conjugate, Concentration: 0.1mg/mL

IL13 109 a.a. Protein

20-abx262191
  • EUR 328.00
  • EUR 5826.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg

CD20(109-3C2) Antibody

BNCR0355-250 250uL
EUR 383
Description: Primary antibody against CD20(109-3C2), RPE conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNUB0355-100 100uL
EUR 209
Description: Primary antibody against CD20(109-3C2), Concentration: 0.2mg/mL

CD20(109-3C2) Antibody

BNUB0355-500 500uL
EUR 458
Description: Primary antibody against CD20(109-3C2), Concentration: 0.2mg/mL

CD20(109-3C2) Antibody

BNC680355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF568 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC680355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF568 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC700355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF770 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC700355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF770 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC800355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF680 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC800355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF680 conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC400355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF640R conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC400355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF640R conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC610355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), CF660R conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNC610355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), CF660R conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNCH0355-100 100uL
EUR 199
Description: Primary antibody against CD20(109-3C2), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNCH0355-500 500uL
EUR 544
Description: Primary antibody against CD20(109-3C2), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD20(109-3C2) Antibody

BNUM0355-50 50uL
EUR 395
Description: Primary antibody against CD20(109-3C2), 1mg/mL

HIST1H1C (Ab-109) Antibody

1-CSB-PA010378OA109nforHU
  • EUR 332.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against HIST1H1C (Ab-109). Recognizes HIST1H1C (Ab-109) from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200

HSC70 ELISA Kit

SKT-106-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit

SKT-107-96 1 plate of 96 wells
EUR 685
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)

SKT-108-96 1 plate of 96 wells
EUR 685
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP60 ELISA Kit

SKT-110-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit

SKT-111-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit

SKT-113-96 1 plate of 96 wells
EUR 633
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit

SKT-123-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)

SKT-124-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit

SKT-126-96 1 plate of 96 wells
EUR 460
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit

SKT-137-96 1 plate of 96 wells
EUR 632
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit

SKT-140-96 1 plate of 96 wells
EUR 566
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Cortisol EIA Kit

SKT-201-96 1 plate of 96 wells
EUR 329
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Glutathione Detection Kit

SKT-202-96 1 plate of 96 wells
EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Glutathione S-Transferase Activity Kit

SKT-203-96 1 plate of 96 wells
EUR 428
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish

Glutathione Reductase Activity Kit

SKT-204-96 1 plate of 96 wells
EUR 428
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human

Corticosterone EIA Kit

SKT-205-96 1 plate of 96 wells
EUR 355
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species

Cortisone CLIA Kit

SKT-206-96 1 plate of 96 wells
EUR 467
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species

Prostaglandin E2 EIA Kit

SKT-207-96 1 plate of 96 wells
EUR 527
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP CLIA Kit (High-Sensitivity)

SKT-208-96 1 plate of 96 wells
EUR 494
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species
Our study elucidated a possible therapeutic efficacy of C70PLY4 in reducing chronic inflammatory conditions and clarified the underlying mechanism. Thus, our findings identify a new drug candidate that, by blocking TLR4 activity, could be an effective treatment for patients with chronic inflammatory diseases.