elispot assay

Perforin ELISpot Assay Kit (Human) (OKDB00025)

OKDB00025 1x96Wells
EUR 532
Description: Description of target: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-2 ELISpot Assay Kit (Human) (OKDB00001)

OKDB00001 1x96Wells
EUR 532
Description: Description of target: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-4 ELISpot Assay Kit (Human) (OKDB00003)

OKDB00003 1x96Wells
EUR 532
Description: Description of target: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-6 ELISpot Assay Kit (Human) (OKDB00005)

OKDB00005 1x96Wells
EUR 532
Description: Description of target: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-10 ELISpot Assay Kit (Human) (OKDB00007)

OKDB00007 1x96Wells
EUR 532
Description: Description of target: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

TNF alpha ELISpot Assay Kit (Human) (OKDB00009)

OKDB00009 1x96Wells
EUR 532
Description: Description of target: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IFN gamma ELISpot Assay Kit (Human) (OKDB00011)

OKDB00011 1x96Wells
EUR 532
Description: Description of target: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-12 ELISpot Assay Kit (Human) (OKDB00013)

OKDB00013 1x96Wells
EUR 532
Description: Description of target: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-5 ELISpot Assay Kit (Human) (OKDB00019)

OKDB00019 1x96Wells
EUR 532
Description: Description of target: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-13 ELISpot Assay Kit (Human) (OKDB00021)

OKDB00021 1x96Wells
EUR 532
Description: Description of target: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

Granzyme B ELISpot Assay Kit (Human) (OKDB00023)

OKDB00023 1x96Wells
EUR 532
Description: Description of target: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-17A ELISpot Assay Kit (Human) (OKDB00027)

OKDB00027 1x96Wells
EUR 532
Description: Description of target: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-17F ELISpot Assay Kit (Human) (OKDB00029)

OKDB00029 1x96Wells
EUR 532
Description: Description of target: The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-2 ELISpot Assay Kit (Murine) (OKDB00033)

OKDB00033 1x96Wells
EUR 532
Description: Description of target: ;Species reactivity: Murine;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IFN gamma ELISpot Assay Kit (Murine) (OKDB00035)

OKDB00035 1x96Wells
EUR 532
Description: Description of target: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.;Species reactivity: Murine;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IFN gamma ELISpot Assay Kit (Rat) (OKDB00037)

OKDB00037 1x96Wells
EUR 532
Description: Description of target: an immune molecule produced by T lymphocytes in response to mitogens or antigens [RGD, Feb 2006];Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

TNF alpha ELISpot Assay Kit (Rat) (OKDB00039)

OKDB00039 1x96Wells
EUR 532
Description: Description of target: acts as a cytokine; binds TNF receptors; plays a role in regulation of cell proliferation, induction of apoptosis, and inflammatory response [RGD, Feb 2006];Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-1 beta ELISpot Assay Kit (Human) (OKDB00017)

OKDB00017 1x96Wells
EUR 532
Description: Description of target: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

IL-17A/F ELISpot Assay Kit (Human) (OKDB00031)

OKDB00031 1x96Wells
EUR 532
Description: Description of target: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISpot Immunoassay;Sensitivity:

GABA conjugate; ELISPOT

CT349 20-plate
EUR 228

GABA conjugate; ELISPOT

CT351 5-plate
EUR 97

QHub ELISpot Reader

MVSCES100 Complete
EUR 32668

Monkey Perforin ELISPOT kit

CT136-PB2 2-plate
EUR 415

Monkey Perforin ELISPOT kit

CT136-PB5 5-plate
EUR 568

Monkey Perforin ELISPOT kit

CT136-PR2 2-plate
EUR 415

Monkey Perforin ELISPOT kit

CT136-PR5 5-plate
EUR 556

Monkey Perforin ELISPOT kit

CT136-T2 2-plate
EUR 360

Monkey Perforin ELISPOT kit

CT136-T5 5-plate
EUR 579

Streptavidin-HRP conjugate; ELISPOT

CT353 5-plate
EUR 103

Human Perforin ELISPOT kit

CT681-PB2 2-plate
EUR 415

Human Perforin ELISPOT kit

CT681-PB5 5-plate
EUR 568

Human Perforin ELISPOT kit

CT681-PR2 2-plate
EUR 415

Human Perforin ELISPOT kit

CT681-PR5 5-plate
EUR 556

Human Perforin ELISPOT kit

CT681-T2 2-plate
EUR 360

Human Perforin ELISPOT kit

CT681-T5 5-plate
EUR 579

Rat IFN-γ ELISPOT kit

CT079-PB2 2-plate
EUR 415

Rat IFN-γ ELISPOT kit

CT079-PB5 5-plate
EUR 568

Rat IFN-γ ELISPOT kit

CT079-PR2 2-plate
EUR 415

Rat IFN-γ ELISPOT kit

CT079-PR5 5-plate
EUR 556

Rat IFN-γ ELISPOT kit

CT079-T2 2-plate
EUR 360

Rat IFN-γ ELISPOT kit

CT079-T5 5-plate
EUR 579

Rat IL-4 ELISPOT kit

CT081-PR2 2-plate
EUR 415

Rat IL-4 ELISPOT kit

CT081-PR5 5-plate
EUR 556

Rat IL-4 ELISPOT kit

CT081-T2 2-plate
EUR 360

Rat IL-4 ELISPOT kit

CT081-T5 5-plate
EUR 579

Monkey G-CSF ELISPOT kit

CT122-PR5 5-plate
EUR 556

Monkey IL-1β ELISPOT kit

CT123-PB2 2-plate
EUR 415

Monkey IL-1β ELISPOT kit

CT123-PB5 5-plate
EUR 568

Monkey IL-1β ELISPOT kit

CT123-PR2 2-plate
EUR 415

Monkey IL-1β ELISPOT kit

CT123-PR5 5-plate
EUR 556

Monkey GM-CSF ELISPOT kit

CT124-PB2 2-plate
EUR 415

Monkey GM-CSF ELISPOT kit

CT124-PB5 5-plate
EUR 568

Monkey GM-CSF ELISPOT kit

CT124-PR2 2-plate
EUR 415

Monkey GM-CSF ELISPOT kit

CT124-PR5 5-plate
EUR 556

Monkey IL-2 ELISPOT kit

CT127-PB2 2-plate
EUR 415

Monkey IL-2 ELISPOT kit

CT127-PB5 5-plate
EUR 568

Monkey IL-2 ELISPOT kit

CT127-PR2 2-plate
EUR 415

Monkey IL-2 ELISPOT kit

CT127-PR5 5-plate
EUR 556

Monkey IL-2 ELISPOT kit

CT127-T2 2-plate
EUR 360

Monkey IL-2 ELISPOT kit

CT127-T5 5-plate
EUR 579

Monkey IL-4 ELISPOT kit

CT128-PB2 2-plate
EUR 415

Monkey IL-4 ELISPOT kit

CT128-PB5 5-plate
EUR 568

Monkey IL-4 ELISPOT kit

CT128-PR2 2-plate
EUR 415

Monkey IL-4 ELISPOT kit

CT128-PR5 5-plate
EUR 556

Monkey IL-4 ELISPOT kit

CT128-T2 2-plate
EUR 360

Monkey IL-4 ELISPOT kit

CT128-T5 5-plate
EUR 579

Monkey IL-5 ELISPOT kit

CT129-PB2 2-plate
EUR 415

Monkey IL-5 ELISPOT kit

CT129-PB5 5-plate
EUR 568

Monkey IL-5 ELISPOT kit

CT129-PR2 2-plate
EUR 415

Monkey IL-5 ELISPOT kit

CT129-PR5 5-plate
EUR 556