Can Low-cost Indo Cyanine Green Florescence Technique for Sentinel Lymph Node Biopsy Replace Dual Dye (Radio-colloid and Blue Dye) Technique in Early Breast Cancer: A Prospective Two-arm Comparative Study.
The objective of this study was to assess the detection and accuracy of sentinel lymph node (SLN) biopsy (SLNB) using the low-cost indocyanine green (ICG) fluorescence method and to compare this method with the gold standard dual-dye method (radio-colloid + methylene blue dye [MB]).
One hundred patients with node-negative early breast cancer assessed clinically and by ultrasound axilla underwent an SLNB procedure using technetium-99m radio-colloid, MB, and ICG. The detection rate of SLNs and positive SLNs and the number of SLNs were compared. The injection safety of ICG and MB was evaluated.One hundred female patients with a median age of 52.3 years participated in the study.
Sixty-eight percent had a body mass index < 25, 85% presented with a palpable lump, of which 59% were in the outer quadrant. SLNs were identified in all 100 cases. A total of 290 SLNs were removed (mean, 2.9; range, 1-6). The identification rate with dual dye was 94%, whereas with ICG alone, it was 96%.
The SLNB sensitivity rate and false negative rate were 97.6% versus 93.2% and 3.1% versus 6.2% in the ICG and dual-dye combination, respectively. None of the patients had any local or systemic reaction with ICG; 3 patients with blue dye had tattooing and staining of skin.ICG fluorescence imaging permits real time visualization of lymphatics and provides an additional dimension to SLN biopsy that is safe and effective.
These results confirm high sensitivity for fluorescence localization with comparable performance to the gold standard. ICG can reliably replace dual dye and be employed as a sole tracer for SLNB in early breast cancer.
 ELISA Kit) Goat Immunoglobulin G (IgG) ELISA Kit |
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| DLR-IgG-g-48T | DL Develop | 48T | EUR 464 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Goat Immunoglobulin G (IgG) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Goat Immunoglobulin G (IgG) ELISA Kit |
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| DLR-IgG-g-96T | DL Develop | 96T | EUR 601 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Goat Immunoglobulin G (IgG) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Goat Immunoglobulin G (IgG) ELISA Kit |
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| RDR-IgG-g-48Tests | Reddot Biotech | 48 Tests | EUR 482 |
Goat Immunoglobulin G (IgG) ELISA Kit |
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| RDR-IgG-g-96Tests | Reddot Biotech | 96 Tests | EUR 667 |
) Histamine [G-BSA] (G-G-BSA) |
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| DAG3327 | Creative Diagnostics | 1mg | EUR 1234 |
, Recombinant (P. Pastoris), purified) Hepatitis Surface Antigen subtype Ayw Mutant G-145-R (HBsAg Ayw mutant), Recombinant (P. Pastoris), purified |
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| HBA29-G-145R | Alpha Diagnostics | 50 ug | EUR 347 |
 Antibody) Cyclin G (Cyclin G) Antibody |
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| 20-abx013056 | Abbexa |
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) Adipokinetic Hormone, G (AKH-G) |
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| 5-00610 | CHI Scientific | 4 x 5mg | Ask for price |
Cyclin G (Cyclin G) Antibody |
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| abx232129-100ug | Abbexa | 100 ug | EUR 481 |
) Nipah virus Glycoprotein G (G) |
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| 1-CSB-CF862323NDT | Cusabio |
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Description: Recombinant Nipah virus Glycoprotein G(G) expressed in in vitro E.coli expression system |
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 Antibody) Leukocyte Antigen G (HLA-G) Antibody |
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| 20-abx136098 | Abbexa |
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 Antibody) Peptidylprolyl Isomerase G (Cyclophilin G) Antibody |
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| 20-abx114386 | Abbexa |
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Leukocyte Antigen G (HLA-G) Antibody |
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| 20-abx109883 | Abbexa |
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Leukocyte Antigen G (HLA-G) Antibody |
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| abx034168-400ul | Abbexa | 400 ul | EUR 523 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx034168-80l | Abbexa | 80 µl | EUR 286 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx034899-100ul | Abbexa | 100 ul | EUR 523 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx034900-400ul | Abbexa | 400 ul | EUR 523 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx034900-80l | Abbexa | 80 µl | EUR 286 |
Leukocyte Antigen G (HLA-G) Antibody |
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| 20-abx009168 | Abbexa |
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Leukocyte Antigen G (HLA-G) Antibody |
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| 20-abx005635 | Abbexa |
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 Protein Kinase G Substrate; G-Subtide |
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| 5-01842 | CHI Scientific | 4 x 5mg | Ask for price |
 R-G-Y-S-L-G |
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| 5-01863 | CHI Scientific | 4 x 5mg | Ask for price |
 G-R-G-D-S-P |
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| 5-01166 | CHI Scientific | 4 x 5mg | Ask for price |
 G-R-G-D-T-P |
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| 5-01167 | CHI Scientific | 4 x 5mg | Ask for price |
 G-R-G-E-T-P |
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| 5-01169 | CHI Scientific | 4 x 5mg | Ask for price |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx413633-02mg | Abbexa | 0.2 mg | EUR 648 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx413634-02mg | Abbexa | 0.2 mg | EUR 648 |
Protein Kinase G Substrate; G-Subtide |
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| 20-abx265631 | Abbexa |
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 Peptide) Adipokinetic Hormone, G (AKH-G) Peptide |
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| 20-abx266348 | Abbexa |
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 Antibody) Major Surface Glycoprotein G (G) Antibody |
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| 20-abx317831 | Abbexa |
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Leukocyte Antigen G (HLA-G) Antibody |
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| 20-abx320348 | Abbexa |
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Leukocyte Antigen G (HLA-G) Antibody |
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| 20-abx215947 | Abbexa |
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 Antibody) Endonuclease G, Mitochondrial (Endo G) Antibody |
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| 20-abx215156 | Abbexa |
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Leukocyte Antigen G (HLA-G) Antibody |
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| abx139501-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139502-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139504-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139506-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139507-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139508-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139512-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139500-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139503-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139505-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139510-01mg | Abbexa | 0.1 mg | EUR 439 |
Leukocyte Antigen G (HLA-G) Antibody |
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| abx139511-01mg | Abbexa | 0.1 mg | EUR 481 |
 Hosenkoside G |
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| HY-N2242 | MedChemExpress | 1mg | EUR 313 |
 Rebaudioside G |
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| HY-N2291 | MedChemExpress | 1mg | EUR 379 |
 G-1 |
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| HY-107216 | MedChemExpress | 10mg | EUR 360 |
 G-749 |
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| HY-12333 | MedChemExpress | 25mg | EUR 481 |
 Thiamet G |
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| HY-12588 | MedChemExpress | 50mg | EUR 601 |
 Alisol G |
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| HY-N0855 | MedChemExpress | 10mg | EUR 739 |
 Gomisin G |
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| HY-N0858 | MedChemExpress | 10mg | EUR 739 |
 Tenacissoside G |
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| HY-N2103 | MedChemExpress | 1mg | EUR 179 |
 G-5555 |
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| HY-19635 | MedChemExpress | 50mg | EUR 785 |
 Saikosaponin G |
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| HY-N4216 | MedChemExpress | 1mg | EUR 443 |
 Kuwanon G |
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| HY-N4247 | MedChemExpress | 10mg | EUR 436 |
 Protein G |
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| P6872 | Bio Basic | 5mg | EUR 137 |
 G-CSF |
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| E21-002 | EnoGene | 10ug | EUR 343 |
 W-G |
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| 5-02089 | CHI Scientific | 4 x 5mg | Ask for price |
 Antagonist G |
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| 5-00704 | CHI Scientific | 0.4 x 5mg | Ask for price |
 Conantokin G |
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| 5-00989 | CHI Scientific | 4 x 1mg | Ask for price |
 G-Q |
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| 5-01165 | CHI Scientific | 4 x 5mg | Ask for price |
 Sulforhodamine g |
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| 80102 | Biotium | 5G | EUR 165 |
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Description: Minimum order quantity: 1 unit of 5G |
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Protein G |
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| abx670070-5mg | Abbexa | 5 mg | EUR 759 |
Protein G |
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| abx670076-1mg | Abbexa | 1 mg | EUR 495 |
Thiamet G |
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| B2048-25 | ApexBio | 25 mg | EUR 350 |
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Description: Thiamet G is a potent and selective inhibitor of O-GlcNAcase with Ki value of 21 nM [1].O-GlcNAcase is an enzyme that removes GlcNAc from proteins. |
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Thiamet G |
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| B2048-5 | ApexBio | 5 mg | EUR 128 |
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Description: Thiamet G is a potent and selective inhibitor of O-GlcNAcase with Ki value of 21 nM [1].O-GlcNAcase is an enzyme that removes GlcNAc from proteins. |
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Thiamet G |
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| B2048-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 131 |
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Description: Thiamet G is a potent and selective inhibitor of O-GlcNAcase with Ki value of 21 nM [1].O-GlcNAcase is an enzyme that removes GlcNAc from proteins. |
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Antagonist G |
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| B5243-1 | ApexBio | 1 mg | EUR 340 |
G-1 |
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| B5455-10 | ApexBio | 10 mg | EUR 273 |
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Description: G-1 is a potent and selective agonist of GPR30 with EC50 value of 2 nM [1].G protein-coupled receptor 30 (GPR30) is an integral membrane protein that localizes to the endoplasmic reticulum and with high affinity for estradiol and aldosterone. |
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 G-15 |
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| B5469-10 | ApexBio | 10 mg | EUR 273 |
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Description: G-15 is a selective antagonist of GPR30 with Ki value of 20 nM [1].G protein-coupled receptor 30 (GPR30) is an integral membrane protein that localizes to the endoplasmic reticulum and with high affinity for estradiol and aldosterone. |
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Conantokin G |
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| B5533-.5 | ApexBio | 500 ug | EUR 399 |
 G-36 |
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| B5707-10 | ApexBio | 10 mg | EUR 273 |
 Cathepsin G |
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| MO20021 | Neuromics | 100 ul | EUR 213 |
 G Antibody |
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| 1-CSB-PA14899A0Rb | Cusabio |
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Description: A polyclonal antibody against G. Recognizes G from Rabies virus. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000 |
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G Antibody |
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| 1-CSB-PA365937LA01HPO | Cusabio |
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Description: A polyclonal antibody against G. Recognizes G from Human respiRatory syncytial virus A. This antibody is Unconjugated. Tested in the following application: ELISA |
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G Antibody |
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| 1-CSB-PA389005LA01RIE | Cusabio |
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Description: A polyclonal antibody against G. Recognizes G from Rabies virus. This antibody is Unconjugated. Tested in the following application: ELISA |
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G Antibody |
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| 1-CSB-PA006050GA01HU | Cusabio |
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Description: A polyclonal antibody against G. Recognizes G from Human. This antibody is Unconjugated. Tested in the following application: ELISA |
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Tenacissoside G |
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| N2128-20 | ApexBio | 20 mg | EUR 282 |
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Description: Extracted from Marsdenia tenacissima (Roxb.) Wight et Arn.;Store the product in sealed, cool and dry condition |
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 g-Endorphin |
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| H-2725.0001 | Bachem | 1.0mg | EUR 151 |
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Description: Sum Formula: C83H131N19O27S; CAS# [60893-02-9] |
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g-Endorphin |
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| H-2725.0005 | Bachem | 5.0mg | EUR 515 |
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Description: Sum Formula: C83H131N19O27S; CAS# [60893-02-9] |
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 Neuropeptide g |
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| H-7455.0500 | Bachem | 0.5mg | EUR 181 |
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Description: Sum Formula: C99H158N34O29S; CAS# [114882-65-4] net |
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Neuropeptide g |
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| H-7455.1000 | Bachem | 1.0mg | EUR 300 |
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Description: Sum Formula: C99H158N34O29S; CAS# [114882-65-4] net |
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G-749 |
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| A8889-1 | ApexBio | 1 mg | EUR 108 |
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Description: G-749 is a selective inhibitor of Fms-like tyrosine receptor kinase-3 (FLT3) with IC50 value of 0.4 nM for wild-type FLT31.G-749 is a synthesized and ATP-competitive inhibitor of wild-type FLT3 with high potency. |
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G-749 |
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| A8889-5 | ApexBio | 5 mg | EUR 212 |
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Description: G-749 is a selective inhibitor of Fms-like tyrosine receptor kinase-3 (FLT3) with IC50 value of 0.4 nM for wild-type FLT31.G-749 is a synthesized and ATP-competitive inhibitor of wild-type FLT3 with high potency. |
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G-749 |
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| A8889-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 422 |
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Description: G-749 is a selective inhibitor of Fms-like tyrosine receptor kinase-3 (FLT3) with IC50 value of 0.4 nM for wild-type FLT31.G-749 is a synthesized and ATP-competitive inhibitor of wild-type FLT3 with high potency. |
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 Sarothralen G |
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| TBZ0831 | ChemNorm | unit | Ask for price |
 Yadanzioside G |
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| TBZ1052 | ChemNorm | unit | Ask for price |
 Budmunchiamine G |
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| TBZ1131 | ChemNorm | unit | Ask for price |
 Heteroclitin G |
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| TBZ1388 | ChemNorm | unit | Ask for price |
 Ixerin G |
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| TBZ1500 | ChemNorm | unit | Ask for price |
 Oleiferin G |
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| TBZ1737 | ChemNorm | unit | Ask for price |
 Senkyunolide G |
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| TBZ1897 | ChemNorm | 20mg | Ask for price |
 Swietemahonin G |
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| TBZ1935 | ChemNorm | unit | Ask for price |
C-Dots and composites based on them face the challenges of poor stability, especially under photo-radiation, and low solid-state photoluminescence quantum yields (PLQYs), which hinder their application in optical devices.
Herein, a novel 2-dimensional hybrid material of polysiloxane embedded with Si-doped carbon dots (P-E-Si-CDs) was synthesized by a self-assembly approach, and the hybrid composite exhibited broadband blue-green fluorescence emission, outstanding photostability, high thermal stability, and a high PLQY of 82.8%.
Moreover, the dual fluorescent emissions were demonstrated the creation of two closed-loop fluorophores.
Using the as-prepared hybrid fluorescent material, fabricated light-emitting diodes (LEDs) based on UV and blue-emitting LED chips present safe warm white light emission and adjustable white emission with a high color rendering index of up to 91, respectively.
This work provides a novel strategy for the design and realization of Si-CD-based hybrid composites, thus promising their prospective use commercially in LED lighting.
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