RecombinantDKK-1,Mouse
594.6 EUR
594.6 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 965 - BK0193
Produktkategori: Företag och industri > Vetenskap och laboratorium
Leverantör:
Gentaur
Storlek: 10μg
Parameters
| Additional information | Dickkopf related protein 1 (DKK1) is a chemokine that belongs to the DKK protein family, which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbate in vitro. DKK-1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK-1 not only functions in head formation during development, but also regulates joint remodeling and bone formation indicating its potential role in the pathogenesis of rheumatoid arthritis and multiple myeloma.Recombinant Mouse Dickkopf-related protein 1 produced in CHO cells is a polypeptide chain containing 243 amino acids. A fully biologically active molecule, rmDKK-1 has a molecular mass of 19~20 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript. |
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BK0193
RecombinantDKK-1,Mouse
ED50 < 6 µg/ml, measured in stimulation of alkaline phosphatase activity using CCl-226 cells.
594.6 €
BK0193
RecombinantDKK-1,Mouse
ED50 < 6 µg/ml, measured in stimulation of alkaline phosphatase activity using CCl-226 cells.
228 €
BK0023
RecombinantDKK-1,Human
ED50 < 6 µg/ml, measured in stimulation of alkaline phosphatase activity using CCl-226 cells. Up to 180% stimulation of alkaline phosphatase activity was observed at 10.0 ug/ml.
1905 €
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