Phospho-Raf1-S259 Rabbit pAb
357.24 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 806 - AP0497
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 20μL
Parameters
| Storage and shipping | Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
|---|
AP0497
Phospho-Raf1-S259 Rabbit pAb
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
357.24 €
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