Palbociclib-propargyl
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On request
quantity
Produktdetaljer
Katalognummer: 931 - T18515-1g
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 1g
Parameters
| Additional information | SMILES: O=C1C(C(=O)C)=C(C=2C=NC(=NC2N1C3CCCC3)NC4=NC=C(C=C4)N5CCN(CC#C)CC5)C; Formula: C27H31N7O2 |
|---|
HY-130296
Palbociclib-propargyl
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1]. Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1207.88 €
HY-A0065
Palbociclib (isethionate)
Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4].
579.3 €
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