HighQC™ Human IPSC-Derived Neural Stem Cell LRRK2 G2019S HET
0.01 EURAsk for quotation
On request
quantity
Produktdetaljer
Katalognummer: 870 - ABC-SC0068T
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 1 vial
ABC-SC0068T
HighQC™ Human IPSC-Derived Neural Stem Cell LRRK2 G2019S HET
Human Human IPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGCandgt;AGC) in the LRRK2 gene. This line is heterozygous for the G2019S mutation where one allele contains the mutation and the other allele is wild type at the locus.The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).
Ask for quotation
ABC-SC0067T
HighQC™ Human IPSC-Derived Neural Stem Cell LRRK2 G2019S HOM
Human Human IPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGCandgt;AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).
Ask for quotation
ABC-SC0070T
HighQC™ Human IPSC-Derived Neural Stem Cell MAPT R406W HET
Human Human IPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the R406W mutation (CGGandamp;gt;TGG) into the MAPT gene. This line is homozygous for the R406W mutation so both alleles contain the mutation.
Ask for quotation