Anti-Phospho-PTEN (S380) PTGDR Antibody
720 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 519 - A06190S380
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 100ul
Parameters
| Additional information | IHC 1:100-1:300;ELISA 1:10000 |
|---|---|
| Storage and shipping | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
STJ11101064
Anti-Phospho-PTEN-S380 antibody
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
857.4 €
A06190S380
Anti-Phospho-PTEN (S380) PTGDR Antibody
Boster Bio Anti-Phospho-PTEN (S380) PTGDR Antibody catalog # A06190S380. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.
720 €
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720 €
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