Anti-Phospho-PTEN-S370 antibody

STJ11101055

Anti-Phospho-PTEN-S370 antibody

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

857.4 €

STJ11101064

Anti-Phospho-PTEN-S380 antibody

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

857.4 €

STJ90397

Anti-Phospho-PTEN (S370) antibody

Rabbit polyclonal to Phospho-PTEN (S370).

504.6 €

A00176T180Y182

Anti-Phospho-p38 (T180/Y182) MAPK14 Antibody

Boster Bio Anti-Phospho-p38 (T180/Y182) MAPK14 Antibody catalog # A00176T180Y182. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

720 €

A03280Y798

Anti-Phospho-PT alpha (Y798) PTPRA Antibody

Boster Bio Anti-Phospho-PT alpha (Y798) PTPRA Antibody catalog # A03280Y798. Tested in ELISA, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat.

720 €

GB113380

Anti-Phospho-p38 (T180/Y182) Rabbit pAb

380 €