![Anti-Phospho-FOXO3a(S253) Antibody [ST49-01]](/images/no-image-product-box.jpg "Anti-Phospho-FOXO3a(S253) Antibody [ST49-01]")
Anti-Phospho-FOXO3a(S253) Antibody [ST49-01]
496.5 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 992 - ET1609-49
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 100ul
Parameters
| Additional information | Synthetic Human Metabotropic Glutamate Receptor 5 aa 1150 to the C-terminus aa 238-282 / 673. |
|---|---|
| Storage and shipping | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
ET1609-49
Anti-Phospho-FOXO3a(S253) Antibody [ST49-01]
FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription factors share the ability to be inhibited and translocated out of the nucleus on phosphorylation by proteins such as Akt/PKB in the PI3K signaling pathway (aside from FOXO6, which may be constitutively nuclear). Other post-translational modifications including acetylation and methylation are seen and can result in increased or altered FOXO3a activity. The use of FOXO3a knockout mice has revealed a diverse range of functions in both health and disease, namely infertility, lymphoproliferation, adenoma, organ inflammation, metabolism etc.; yet despite the purported importance of FOXO transcription factors in aging, FOXO3A knockout mice do not show an obvious shortening of lifespan or accelerated aging.
496.5 €
A00073S329
Anti-Phospho-FoxO1A (S329) Antibody
Boster Bio Anti-Phospho-FoxO1A (S329) Antibody catalog # A00073S329. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
720 €
STJ90275
Anti-Phospho-FoxO3A (S253) antibody
FoxO3A is a protein encoded by the FOXO3 gene which is approximately 71,2 kDa. FoxO3A is localised to the cytoplasm and nucleus. It is involved in RET signalling, GAB1 signalosome, glioma and common cytokine receptor gamma-chain family signalling pathways. It is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It also participates in post-transcriptional regulation of MYC. FoxO3A is expressed ubiquitously. Mutations in the FOXO3 gene may result in secondary acute leukemia. STJ90275 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous FoxO3A protein which only binds about S253 when S253 is phosphorylated.
504.6 €
STJ90899
Anti-Phospho-FAK (Y397) antibody
FAK is a protein encoded by the PTK2 gene which is approximately 119,2 kDa. FAK is localised to the cell membrane and cytoplasm. It is involved in ERK signalling, integrin pathway and EPH-ephrin signalling. It is a non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. FAK is ubiquitously expressed with Isoform 1 and isoform 6 expressed in lung fibroblasts. Mutations in the PTK2 gene may result in malignant glioma. STJ93024 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of FAK protein only when phosphorylated at Y397.This primary antibody specifically binds to endogenous FAK protein which only binds about Y397 when Y397 is phosphorylated.
504.6 €
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