Anti-Phospho-BRCA2 (S3291) antibody

A00009S3291

Anti-Phospho-BRCA2 (S3291) Antibody

Boster Bio Anti-Phospho-BRCA2 (S3291) Antibody catalog # A00009S3291. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

720 €

STJ90672

Anti-Phospho-BRCA2 (S3291) antibody

Rabbit polyclonal to Phospho-BRCA2 (S3291).

504.6 €

STJ11100965

Anti-Phospho-BRCA1-S1524 antibody

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

857.4 €

STJ29341

Anti-Phospho-BCL2-(S70) antibody

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

857.4 €

STJ29372

Anti-Phospho-BCR-(Y177) antibody

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

857.4 €

STJ502178

Anti-Phospho-BTK Antibody FITC

1311 €