Anti-MCL1 Antibody [SI16-04]

ET1606-14

Anti-MCL1 Antibody [SI16-04]

B-cell CLL/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.

496.5 €

G088

Anti-MCL1 Antibody

453.5 €

E38A1726

Anti-MCL1 Antibody

Available in various conjugation types.

487.5 €

M00712

Anti-MCL1 Rabbit Monoclonal Antibody

WB 1:500-1:2000 ;IHC 1:50-1:200 ;ICC/IF 1:50-1:200 ;IP 1:50 ;Flow Cytometry 1:50

381 €

MBS179422-01mL

Anti-MCL1 Rabbit Monoclonal Antibody

758.75 €

MBS179422-5x01mL

Anti-MCL1 Rabbit Monoclonal Antibody

2569.25 €