Anti-Mcl-1 Antibody

A00712

Anti-Mcl-1 Antibody

Boster Bio Anti-Mcl-1 Antibody (Catalog # A00712). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

823.5 €

GWB-63CB86

Anti-Mcl-1 Antibody

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STJ94044

Anti-Mcl-1 antibody

Mcl-1 is a protein encoded by the MCL1 gene which is approximately 37,3 kDa. Mcl-1 is localised to the cell membrane, cytoplasm, mitochondrion and nucleus. It is involved in apoptosis modulation and signalling, the Jak-STAT signalling pathway, cytokine signalling in the immune system and the PI3K-Akt signalling pathway. It regulated of apoptosis and cell survival, and plays a role in the maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes apoptosis. Mcl-1 is expressed in the nervous system, blood, lung, bone marrow and liver. Mutations in the MCL1 gene may result in myeloid leukaemia and follicular lymphoma. STJ94044 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Mcl-1 protein.

504.6 €

ET1606-14

Anti-MCL1 Antibody [SI16-04]

B-cell CLL/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.

496.5 €

A00712-2

Anti-MCL1 Antibody Picoband™

Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat;_x000D_Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human; _x000D_Flow Cytometry, 1-3 μg /1x10⁶ cells, Human;_x000D_Direct ELISA, 0.1-0.5 μg/ml, Human

381 €

PB9132

Anti-MCL1 Antibody Picoband™

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat;Western blot, 0.1-0.5μg/ml, Human, Rat

381 €