TGF/SMAD Signaling Pathway SBE Report Cell Line-HEK293
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Catalog number: 870 - ABC-RC122D
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 1 vial
ABC-RC122D
TGF/SMAD Signaling Pathway SBE Report Cell Line-HEK293
The SBE Reporter andndash; HEK293 Cell Line is designed for monitoring the activity of the TGF /SMAD signaling pathway. The transforming growth factor beta (TGF) signaling pathway is involved in a diverse range of cell processes such as differentiation, cell cycle arrest, and immune regulation. TGF signaling has been linked to cardiac disease, cancer, Alzheimerandrsquo;s and other human diseases. TGF proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to phosphorylation and activation of SMAD2 and SMAD3, which then form a complex with SMAD4. The SMAD complex then translocates to the nucleus and binds to the SMAD binding element (SBE) in the nucleus, leading to transcription and expression of TGF / SMAD responsive genes.
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60653
TGF/SMAD Signaling Pathway SBE Reporter - HEK293 Cell Line
The SBE Reporter - HEK293 Cell Line is designed for monitoring the activity of the TGF /SMAD signaling pathway. The transforming growth factor beta (TGF ) signaling pathway is involved in a diverse range of cell processes such as differentiation, cell cycle arrest, and immune regulation. TGF signaling has been linked to cardiac disease, cancer, Alzheimer's and other human diseases. TGF proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to phosphorylation and activation of SMAD2 and SMAD3, which then form a complex with SMAD4. The SMAD complex then translocates to the nucleus and binds to the SMAD binding element (SBE) in the nucleus, leading to transcription and expression of TGF / SMAD responsive genes.
3946.57 €
ABC-RC119D
AP-1 Report Cell Line-HEK293(JNK signaling pathway)
The AP-1 Reporter – HEK293 Cell Line is designed for monitoring the activity of the JNK signaling pathway. The AP1 Reporter – HEK293 cell line contains a firefly luciferase gene under the control of AP1-responsive elements that are stably integrated into HEK293 cells.
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79298
NFAT Reporter - Hek293 Cell Line (PKC/ Ca2+ Pathway)
The NFAT Reporter - Hek293 cell line contains a firefly luciferase gene under the control of NFAT response element stably integrated into Hek293 cells. This cell line is validated for the response to the stimulation of phorbol 12-myristate 13-acetate (PMA) with ionomycin.
3393.60 €
60510
ISRE Reporter-HEK293 Recombinant Cell Line (JAK pathway)
The ISRE Reporter - HEK293 Cell Line is designed for monitoring the activity of the JAK/STAT signaling pathway. The ISRE Reporter - HEK293 Cell Line contains the firefly luciferase gene under the control of ISRE stably integrated into HEK293 cells.
3598.13 €
78327
SRE eGPF Reporter - HEK293 Cell Line (ERK Pathway)
Recombinant HEK-293 cells expressing enhanced green fluorescent protein (eGFP) under the control of SRE responsive elements. This cell line is validated for its response to EGF or serum stimulation and to treatment with inhibitors of ERK signaling pathway.