Phospho-STAT6-Y641 Rabbit pAb

AP0456

Phospho-STAT6-Y641 Rabbit pAb

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

463.51 €

AP0456-100ul

Phospho-STAT6-Y641 Rabbit pAb

841.2 €

AP0456-200ul

Phospho-STAT6-Y641 Rabbit pAb

1147.2 €

AP0858-20ul

Phospho-STAT1-Y701 Rabbit pAb

479.4 €

AP0858-50ul

Phospho-STAT1-Y701 Rabbit pAb

627 €

AP0887

Phospho-STAT5-Y694 Rabbit pAb

Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.

723.88 €