Phospho-MLKL-S358 Rabbit pAb
1249.95 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 806 - AP1244
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 20μL
Parameters
| Storage and shipping | Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
|---|
AP1244
Phospho-MLKL-S358 Rabbit pAb
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
1249.95 €
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