Peretinoin
729.94 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 804 - HY-100008
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 10mM/1mL
Parameters
| Storage and shipping | -20°C (Powder, protect from light, stored under nitrogen) |
|---|
HY-100008
Peretinoin
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].
729.94 €
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