OKCD00764-96W - PDGFC ELISA Kit (Mouse)

OKCD00764-96W

OKCD00764-96W - PDGFC ELISA Kit (Mouse)

1207 €

OKCD00764

PDGFC ELISA Kit (Mouse) (OKCD00764)

Description of target: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.8 Publications&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.6"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."_x005F_x005F_x000D_Li X., Ponten A., Aase K., Karlsson L., Abramsson A., Uutela M., Backstrom G., Hellstrom M., Bostrom H., Li H., Soriano P., Betsholtz C., Heldin C.H., Alitalo K., Ostman A., Eriksson U._x005F_x005F_x000D_Nat. Cell Biol. 2:302-309(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE.Ref.7"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."_x005F_x005F_x000D_Gilbertson D.G., Duff M.E., West J.W., Kelly J.D., Sheppard P.O., Hofstrand P.D., Gao Z., Shoemaker K., Bukowski T.R., Moore M., Feldhaus A.L., Humes J.M., Palmer T.E., Hart C.E._x005F_x005F_x000D_J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.Ref.10"Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy."_x005F_x005F_x000D_Ponten A., Li X., Thoren P., Aase K., Sjoblom T., Ostman A., Eriksson U._x005F_x005F_x000D_Am. J. Pathol. 163:673-682(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis."_x005F_x005F_x000D_Zhuo Y., Zhang J., Laboy M., Lasky J.A._x005F_x005F_x000D_Am. J. Physiol. 286:L182-L188(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY BLEOMYCIN.Ref.14"Tissue plasminogen activator is a potent activator of PDGF-CC."_x005F_x005F_x000D_Fredriksson L., Li H., Fieber C., Li X., Eriksson U._x005F_x005F_x000D_EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, ACTIVATION BY PROTEOLYTIC CLEAVAGE.Ref.15"A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling."_x005F_x005F_x000D_Ding H., Wu X., Bostrom H., Kim I., Wong N., Tsoi B., O'Rourke M., Koh G.Y., Soriano P., Betsholtz C., Hart T.C., Marazita M.L., Field L.L., Tam P.P., Nagy A._x005F_x005F_x000D_Nat. Genet. 36:1111-1116(2004) [PubMed] [Europe PMC] [Abstract]Cited for: DISRUPTION PHENOTYPE, FUNCTION.Ref.16"Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis."_x005F_x005F_x000D_Yang D., Qiu D._x005F_x005F_x000D_Eur. Heart J. 26:642-643(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION BY COXSACKIEVIRUS B3 INFECTION, DISEASE.Ref.22"PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis."_x005F_x005F_x000D_Eitner F., Bucher E., van Roeyen C., Kunter U., Rong S., Seikrit C., Villa L., Boor P., Fredriksson L., Backstrom G., Eriksson U., Ostman A., Floege J., Ostendorf T._x005F_x005F_x000D_J. Am. Soc. Nephrol. 19:281-289(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 12.1 pg/mL

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