OKBB01300
Description of target: Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene. It is mapped to 4q34. This protein is involved in caspase-dependent apoptosis and in Parkinson's disease. Protein HtrA2, also known as Omi, is a mitochondrially-located serine protease. The human protein Serine protease HTRA2, mitochondrial is 49kDa in size and composed of 458 amino acids. The peptide fragment of 1-31 amino acid is the mitochondrial transition sequence, fragment 32-133 amino acid is propertied, and 134-458 is the mature protein Serine protease HTRA2, mitochondrial, and its theoretical pI of this protein is 6.12. HtrA2 shows similarities with DegS, a bacterial protease present in the periplasm of gram-negative bacteria. Structurally, HtrA2 is a trimeric molecule with central protease domains and a carboxy-terminal PDZ domain, which is characteristic of the HtrA family. The PDZ domain preferentially binds C-terminus of the protein substrate and modulate the proteolytic activity of the trypsin-like protease domain.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml
1066 €