Myc Report Cell Line(Luc)–HCT116 (Myc Signaling Pathway)
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Catalog number: 870 - ABC-RC115D
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 1 vial
ABC-RC115D
Myc Report Cell Line(Luc)–HCT116 (Myc Signaling Pathway)
The Myc Reporter andndash; HCT116 cell line contains the firefly luciferase gene under the control of Myc responsive elements stably integrated into HCT116 cells, a human colon cancer cell line. HCT116 contains a mutated beta-catenin which leads to the accumulation of andbeta; -catenin and constitutive activation of downstream Myc that induces the expression of Myc luciferase reporter. The cell line is validated for the inhibition of the expression of Myc luciferase reporter.
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ABC-RC119D
AP-1 Report Cell Line-HEK293(JNK signaling pathway)
The AP-1 Reporter – HEK293 Cell Line is designed for monitoring the activity of the JNK signaling pathway. The AP1 Reporter – HEK293 cell line contains a firefly luciferase gene under the control of AP1-responsive elements that are stably integrated into HEK293 cells.
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ABC-RC122D
TGF/SMAD Signaling Pathway SBE Report Cell Line-HEK293
The SBE Reporter andndash; HEK293 Cell Line is designed for monitoring the activity of the TGF /SMAD signaling pathway. The transforming growth factor beta (TGF) signaling pathway is involved in a diverse range of cell processes such as differentiation, cell cycle arrest, and immune regulation. TGF signaling has been linked to cardiac disease, cancer, Alzheimerandrsquo;s and other human diseases. TGF proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to phosphorylation and activation of SMAD2 and SMAD3, which then form a complex with SMAD4. The SMAD complex then translocates to the nucleus and binds to the SMAD binding element (SBE) in the nucleus, leading to transcription and expression of TGF / SMAD responsive genes.
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ABC-RC132D
Luciferase(Puromycin) Report Cell Line-CFPAC-1
Transformed from human human pancreatic cancer cell line, CFPAC-1 adhesive epithelial cell, using lentivirus expressing firefly luciferase 3 gene. The Luciferase was expressed under the enhanced EF1a promoter. The Puromycin marker was expressed under Rsv promoter. The cell line demonstrates high level of bioluminescence signal via firefly luciferase assay.
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ABC-RC135D
Luciferase(Puromycin) Report Cell Line-Jurkat T
Transformed from human Jurkat T lymphocyte suspension cells using lentivirus expressing firefly luciferase gene. The Luciferase was expressed under the enhanced EF1a promoter. The Puromycin marker was expressed under Rsv promoter. The cell line demonstrates high level of bioluminescence signal via firefly luciferase assay.
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ABC-RC137D
Luciferase(firefly) Report Cell Line(Puromycin)-CRE
Transformed from HEK293 cells by lentiviral system with sequence verified firefly luciferase gene II and CRE recombinase. Luciferase and CRE was co-expressed under CMV promoter as seperated protein(not as fusion). The Puromycin marker was expressed under Rsv promoter. The cell constitutively co-expresses both firefly Luciferase and CRE.