Monoclonal Anti-SN38 Antibody, Mouse IgG1 (MALS verified)

SN8-M685

Monoclonal Anti-SN38 Antibody, Mouse IgG1 (MALS verified)

SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.

5459.16 €

SN8-S223

Monoclonal Anti-SN38 Antibody (MALS verified)

SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.

1011.96 €

SN8-S223-100ug

Monoclonal Anti-SN38 Antibody (MALS verified)

Monoclonal Anti-SN38 Antibody, is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with SN38.

1011.96 €

MBS190264-02mg

Human Transcription Factor IIB MonoclonalAntibody

784.25 €

MBS190264-5x02mg

Human Transcription Factor IIB MonoclonalAntibody

2881.62 €

CSB-MA187707I1m-100ul

SN38 Monoclonal Antibody

>95%, Protein G purified

705 €