Monoclonal Anti-SN38 Antibody (MALS verified)

SN8-S223

Monoclonal Anti-SN38 Antibody (MALS verified)

SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.

1011.96 €

SN8-S223-100ug

Monoclonal Anti-SN38 Antibody (MALS verified)

Monoclonal Anti-SN38 Antibody, is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with SN38.

1011.96 €

SN8-S223-1mg

Monoclonal Anti-SN38 Antibody (MALS verified)

Monoclonal Anti-SN38 Antibody, is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with SN38.

5616.12 €

CSB-RA187707I1m-100ul

SN38 Recombinant Monoclonal Antibody

705 €

CSB-RA187707I1m-50ul

SN38 Recombinant Monoclonal Antibody

705 €

TNA-BLM494

Biotinylated Monoclonal Anti-TNF-alpha Antibody, human IgG1 (16H5) (MALS verified)

Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

593.4 €