Human Schwann Cells

CSC-C9380W

Human Schwann Cells 

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ABC-TC3793

Human Schwann Cells

Schwann cells are neural crest derivatives that ensheathe and myelinate axons of peripheral nerves. They wrap individually around the shaft of peripheral axons, forming myelin sheath along segments of the axon. The cytoplasm and the nuclei of the Schwann cells which lie outside theandnbsp;myelinandnbsp;sheath are collectively called theandnbsp;neurilemma (also called neurolemma).<br /Schwann cells are the myelinating cells in the peripheral nervous system (PNS),andnbsp;play important roles in the development, function and regeneration of peripheral nerves. When an axon is dying, the Schwann cells surrounding it aid in its digestion. This leaves an empty channel formed by successive Schwann cells, through which a new axon may grow from a severed end. The number of Schwann cells in peripheral nerve is tightly regulated. Their proliferation in vitro can be stimulated by growth factors including PDGF, FGF, neuregulin and others. The Schwann cells provide a relatively simple, well-defined and accessible mammalian model for the study of a number of developmental questions. It is also of particular clinical importance to understand the biology of Schwann cells, not only in the context of neuropathies and nerve regeneration, but also because the cells or their precursor might be especially well suited as implants to facilitate repair in the CNS.HSC from Gentaur Research Laboratories are isolated from human spinal nerves. HSC are cryopreserved at passage one and delivered frozen. Each vial contains andgt;5×10^5 cells in 1 ml volume. HSC are characterized by immunofluorescent method with antibodies to S-100, GFAP and CD90. HSC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HSC are guaranteed to further culture in the conditions provided by Gentaur Research Laboratories.

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HMP303

Human Schwann Cells

1994.66 €

ABC-TC3700

Human Meningeal Cells

Meningeal cells surrounding the brain participate actively in the normal development of the central nervous system. For example, they play important roles in both stabilizing the extracellular matrix of the pial surface and by organizing the radial glial scaffold and the lamination of the cerebellar cortex. Selective pharmacological destruction of the meningeal cells during a critical ontogenetic period leads to specific malformation of both the cerbella cortex and dentate gyrus. Grafts of meningeal cells, which derived form meninges overlying the cerebral cortex, in adult rat spinal cord lesion promote axonal regrowth. In vitro study shows that meningeal cell chemotactically orient the migration of immature neurons.HMC from Gentaur Research Laboratories are isolated from human leptomeningi. HMC are cryopreserved at primary culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HMC are characterized by immunofluorescent method with antibodies to fibronectin and negative to GFAP, alpha-smooth muscle actin and Thy 1.1. HMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HMC are guaranteed to further expand for 5 population doublings at the condition provided by Gentaur Research Laboratories.

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ABC-TC3973

Human Dendritic Cells

Normal Human Dendritic Cells do not proliferate and can survive up to 7 days in culture with the proper cytokines (IL-4 and GM-CSF). All dendritic cells are isolated from peripheral blood by apheresis and density gradient centrifugation.

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ABC-TC3618

Human Fibroblast Cells

Primary Human Fibroblast Cells are pooled primary isolates from 250 individual neonatal donor foreskins.These cells were originated using Complete Serum-Free Medium Kit With AcceSup™, are available at <12 Cumulative Population Doublings (CPD) in vitro [Passage 3] and were cryopreserved in aliquots of ~1.5×10^6 cells. This vial will initiate a Passage 4 cell culture in a 75cm2 flask.These cells are available in both cryopreserved vials as well as in 25cm2 and 75cm2 proliferating culture flasks.Each vial or flask of cells is shipped to Customer with Bac-O (antibiotic) and AcceSup™ (animal derived growth factors) or AcceSup-R™ (human recombinant growth factors) at no additional cost.

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