Katalognummer: 749 - KTE60331-48T
Produktkategori: Företag och industri > Vetenskap och laboratorium
Storlek: 48T
Additional information | SPNS2 contains 548 amino acids and shares significant homology with zebrafish Spns2. Kawahara et al. (2009) showed that zebrafish Spns2, which contains 12 transmembrane domains, was expressed at the membrane of transfected Chinese hamster ovary cells. Overexpression of either zebrafish or human SPNS2 increased the release of sphingosine-1-phosphate (S1P) into the culture medium. Kawahara et al. (2009) concluded that SPNS2 functions as an S1P transporter in S1P secretion.an N-ethyl-N-nitrosurea-induced arg153-to-ser mutation in zebrafish Spns2 led to cardiac bifida. Expression of human SPNS2, but not human SPNS1 , reversed the defect. The defect was also rescued by S1P injection or by reintroduction of zebrafish Spns2 in extraembryonic tissue yolk syncytial layer. |
---|---|
Storage and shipping | Storage: The unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.Shipping:Gel pack with blue ice. |
By: Author , 2 Comment
30 August 2025
By: Author , 2 Comment
23 August 2025
By: Author , 2 Comment
16 August 2025
By: Author , 2 Comment
8 August 2025