Human Conjunctival Fibroblasts

ABC-TC3574

Human Conjunctival Fibroblasts

The fibroblast is the cellular element responsible for fibrosis. Conjunctival fibroblasts, as other fibroblasts, act not only as structural cells in the production of the matrix components, but are also actively involved as effectors in allergic conjunctivitis. Conjunctival fibroblasts cultured with histamine induce the production of proinflammatory cytokines, such as IL-1, IL-6 and IL-8. Conjunctival fibroblast culture can serve as a useful in vitro model for rapid screening of drugs for their effect on fibroblast morphology, motility, and proliferation, and provide a basis for the development of new treatments for a variety of ocular proliferative disorders.HConF from Gentaur Research Laboratories are isolated from human conjunctiva. HConF are cryopreserved at primary culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HConF are characterized by their spindle morphology and immunofluorescent method with antibody to fibronectin. HConF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HConF are guaranteed to further expand for 15 population doublings at the condition provided by Gentaur Research Laboratories.

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T0375

Immortalized Human Conjunctival Fibroblasts - HPV E6/E7

4241 €

ABC-TC3573

Human Conjunctival Epithelial Cells

The conjunctival epithelium is a stratified, non-keratinized epithelium. It can be distinguished by the corneal epithelium by the expression of different cytokeratins, mucins and by the presence of glycocalix. Decrease or loss of mucin/glycocalix production generates squamous metaplasia, which may lead to dry eye and ocular surface diseases. Human conjunctival epithelial cells represent potential target cells for mast cell mediators. They respond to histamine by generating inositol phosphates, mobilizing intracellular calcium, and then secreting proinflammatory cytokines like interleukin-6 and interleukin-8.HConEC from Gentaur Research Laboratories are isolated from human conjunctiva. HConEC are cryopreserved from passage one culture. Each vial contains 5×10^5 cells in 1 ml volume. HConEC are characterized by their cobble stone morphology in serum-free culture and immunofluorescent method with antibody to CK-18 and -19. HConEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HConEC are guaranteed to further expand for 10 population doublings at the condition provided by Gentaur Research Laboratories.

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P0020022

Human Dermal Fibroblasts (HDFa)

1000 €

ABC-TC3029

Human Dermal Fibroblasts, Adult

Human Dermal Fibroblasts-Adult are isolated from adult human skin. Human Dermal Fibroblasts-Adult are cryopreserved at P0 and delivered frozen. Human Dermal Fibroblasts-Adult are characterized by their spindle morphology and immunofluorescence with antibody specific to fibronectin. Human Dermal Fibroblasts-Adult are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi.Human Dermal Fibroblasts provide an ideal cell system to establish serum free human feeder layers for human embryonic stem cell cultures or as a model to study wound healing, toxicology or basic cell biology. Fibroblasts are cryopreserved as primary cells to ensure the highest viability and plating efficiency.

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ABC-TC3588

Human Dermal Fibroblasts, Fetal

Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies. This is mainly because they are one of easiest types of cells to grow in culture, and their durability makes them amenable to a wide variety of manipulations ranging from studies employing gene transfection to microinjection. There is good evidence that fibroblasts in different parts of the body are intrinsically different. Fibroblasts within tissues are exposed to a dynamic mechnical environment, which influences the structure integrity of both healthy and healing soft tissue. Fibroblasts secrete a nonrigid extracellular matrix that is rich in type I and/or type III collagen. In addition, dermal fibroblasts also secrete large quantities of hyaluronan in response to inflammatory stimuli. During wound healing, dermal fibroblasts switch from a migratory, repopulating phenotype to a contractile, matrix-reassembling phenotype.HDF from Gentaur Research Laboratories are isolated from fetal human skin. HDF are cryopreserved at primary culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HDF are characterized by their spindle morphology and immunofluorescent method with antibody to fibronectin. HDF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HDF are guaranteed to further expand for 15 population doublings at the condition provided by Gentaur Research Laboratories.

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