Human CD40 Ligand Recombinant Protein (Animal Free) Lyophilized

IHUCD40LGRAFLY10UG

Human CD40 Ligand Recombinant Protein (Animal Free) Lyophilized

Human CD40 Ligand Recombinant Protein (Animal Free) Lyophilized

689.5 €

MBS8431568-INQUIRE

Human CD40 Ligand Recombinant Protein (Animal Free) Lyophilized

Ask for quotation

100-115-AF

Human CD40-Ligand (Animal Free) Recombinant Protein

CD40, a member of the TNF receptor superfamily, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells.  Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching.  The membrane-anchored CD40 Ligand is expressed almost exclusively on activated CD4+ T lymphocytes.  Failure to express CD40L leads to “immunodeficiency with hyper-IgM”, a disease characterized by failure to produce IgG, IgA and IgE.  The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain.  The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L.  Recombinant Human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.

494.92 €

Z100127

Recombinant Human CD40 Ligand (CD40LG)

CD40LG protein is expressed on all B lymphocytes during various stages of development, activated T cells and monocytes, follicular dendritic cells, thymic epithelial cells, and various carcinoma cell lines. It is expressed on most mature B cell malignancies and on some early B cell acute lymphocytic leukemias. Human CD40LG has been found to be the receptor for a protein involved in an X-linked immunodeficiency syndrome. Based on its homology with other members of the TNF ligand protein superfamily, CD40LG is also referred to also as TNFSF5. The soluble form of CD40LG is generated by the intracellular proteolytic processing of the full length CD40LG. Recombinant Human CD40LG is a 17 kDa protein that represents the soluble segment of full length CD40LG and encompasses the receptor binding TNF-like domain.

566 €

Z100129

Recombinant Human CD40 Ligand (CD40LG)

CD40LG protein is expressed on all B lymphocytes during various stages of development, activated T cells and monocytes, follicular dendritic cells, thymic epithelial cells, and various carcinoma cell lines. It is expressed on most mature B cell malignancies and on some early B cell acute lymphocytic leukemias. Human CD40LG has been found to be the receptor for a protein involved in an X-linked immunodeficiency syndrome. Based on its homology with other members of the TNF ligand protein superfamily, CD40LG is also referred to also as TNFSF5. The soluble form of CD40LG is generated by the intracellular proteolytic processing of the full length CD40LG. Recombinant Human CD40LG is a 17 kDa protein that represents the soluble segment of full length CD40LG and encompasses the receptor binding TNF-like domain.

1623.5 €

CSB-RP060054h-10ug

Human CD40 ligand (CD40LG)

Recombinant Human CD40 ligand(CD40LG),partial expressed in E.coli

362 €