Human B7-1 / CD80 Protein, Fc Tag (MALS verified)
541.08 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 716 - B71-H5259
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 1mg
Parameters
| Additional information | B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response.B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
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| Storage and shipping | -20℃ RT |
B71-H5259
Human B7-1 / CD80 Protein, Fc Tag (MALS verified)
Human B7-1, Fc Tag (B71-H5259) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # NP_005182.1).
541.08 €
B71-H5228
Human B7-1 / CD80 Protein, His Tag (MALS verified)
Human B7-1, His Tag (B71-H5228) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # P33681-1).
593.4 €
B71-H52A4
Human B7-1 / CD80 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
Human B7-1, Mouse IgG2a Fc Tag (B71-H52A4) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # P33681-1).
2895.48 €
2B4-H5255
Human 2B4 / CD244 / SLAMF4 Protein, Fc Tag
Human 2B4, Fc Tag (2B4-H5255) is expressed from human 293 cells (HEK293). It contains AA Cys 22 - Arg 221 (Accession # Q9BZW8-2).
528 €
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