HIF1A Chemi-Luminescent ELISA Kit (Mouse) (OKCD03558)

OKCD03558

HIF1A Chemi-Luminescent ELISA Kit (Mouse) (OKCD03558)

Description of target: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia .;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 31.2 pg/mL

2005.6 €

OKCD03558-96W

OKCD03558-96W - HIF1A Chemi-Luminescent ELISA Kit (Mouse)

1432 €

OKCD03559

HIF1A Chemi-Luminescent ELISA Kit (Pig) (OKCD03559)

Description of target: ;Species reactivity: Pig;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL

2239.6 €

OKCD00167

HIF1A ELISA Kit (Pig) (OKCD00167)

Description of target: ;Species reactivity: Pig;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 5.5 pg/mL

1769.8 €

AM50284PU-S

HIF-1 alpha (HIF1A) mouse monoclonal antibody, clone HIF1A-84, Purified

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AM50284PU-T

HIF-1 alpha (HIF1A) mouse monoclonal antibody, clone HIF1A-84, Purified

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