FM26
0.01 EURAsk for quotation
On request
quantity
Produktdetaljer
Katalognummer: 931 - T11308-5mg
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 5mg
Parameters
| Additional information | SMILES: O=C(O)C1=CC=C(C=C1)NCC=2C(=NOC2C=3C=CNC3)C=4C(Cl)=CC=CC4C(F)(F)F; Formula: C22H15ClF3N3O3 |
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HY-133128
FM26
FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
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HY-149277
FM04
FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM). FM04 inhibits P-gp in 2 mechanism: (1)FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2)FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp[1].
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HY-15672
FM19G11
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions[1][2].
1129.95 €
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