EGFR-IN-16
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On request
quantity
Produktdetaljer
Katalognummer: 931 - T8525-1g
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 1g
Parameters
| Additional information | SMILES: OC1=C(O)C=C(\\C=C(/C#N)C(=O)C2=CC=CC=C2)C=C1; Formula: C16H11NO3 |
|---|
HY-137786
EGFR-IN-16
EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC50 of 4.85 and 4.74 for EGFR and HER-2, respectively[1].
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HY-145844
EGFR-IN-44
EGFR-IN-44 (Compound 6a) is a potent, orally active EGFR tyrosine kinase inhibitor with an IC50 of 4.11 nM. EGFR-IN-44 induces cell apoptosis and shows an oral bioavailability value of 33.57%. EGFR-IN-44 can be studied for non-small-cell lung cancers[1].
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HY-145867
EGFR-IN-45
EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC50s of 0.4 µM and 1.6 µM for EGFR and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis[1].
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HY-146132
EGFR-IN-55
EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].
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