Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)

Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)

436.44 EUR

436.44 EUR
In Stock
quantity
Produktdetaljer

Katalognummer: 716 - ALN-C52H5

Produktkategori: Företag och industri > Vetenskap och laboratorium

Leverantör:

ACROBIOSYSTEMSGentaur

Storlek: 1mg

Parameters

Additional informationNeuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
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