Biotinylated Human LRRC15 / LIB Protein, Fc,Avitag™ (MALS verified)
658.8 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 716 - LR5-H82F9
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 200ug
Parameters
| Additional information | LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies. |
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| Storage and shipping | -20℃ RT |
LR5-H82F9
Biotinylated Human LRRC15 / LIB Protein, Fc,Avitag™ (MALS verified)
Biotinylated Human LRRC15 Protein, Fc,Avitag (LR5-H82F9) is expressed from human 293 cells (HEK293). It contains AA Tyr 22 - Gly 538 (Accession # Q8TF66-1).
658.8 €
LR5-H82E4
Biotinylated Human LRRC15 / LIB Protein, His,Avitag™ (MALS verified)
Biotinylated Human LRRC15, His,Avitag (LR5-H82E4) is expressed from human 293 cells (HEK293). It contains AA Tyr 22 - Gly 538 (Accession # Q8TF66-1).
2215.32 €
MRM-H82W5
Biotinylated Human MR1&B2M Complex Protein (MALS verified)
Biotinylated Human MR1&B2M Complex Protein (MRM-H82W5) is expressed from human 293 cells (HEK293). It contains AA Arg 23 - Met 302 (Accession # Q95460-1 (MR1) & P61769-1 (B2M)).
1103.52 €
PT7-H82F5
Biotinylated Human PTK7 / CCK4 protein, Fc,Avitag™ (MALS verified)
Biotinylated Human PTK7 protein, Fc,Avitag (PT7-H82F5) is expressed from human 293 cells (HEK293). It contains AA Ala 31 - Thr 704 (Accession # Q13308-1).
684.96 €
SE6-H82E3
Biotinylated Human SEZ6 Protein, His,Avitag™ (MALS & SPR verified)
Biotinylated Human SEZ6 Protein, His,Avitag (SE6-H82E3) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - His 925 (Accession # Q53EL9-1).
2019.12 €
AC2-H82E6
Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)
Biotinylated Human ACE2, His,Avitag (AC2-H82E6) is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Ser 740 (Accession # Q9BYF1-1).
2490 €
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