![APC Anti-Mouse CD80 Antibody[16-10A1]](/images/no-image-product-box.jpg "APC Anti-Mouse CD80 Antibody[16-10A1]")
APC Anti-Mouse CD80 Antibody[16-10A1]
16088 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 763 - E-AB-F0992E-100Tests2
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 100Tests×2
Parameters
| Additional information | 5 uL/Test |
|---|---|
| Storage and shipping | Biological Ice Packs |
RF16042-01mg
CD80 Antibody [10A1]
CD80 Antibody: CD80, also known as B7-1, is a type I membrane protein that is a member of the immunoglobulin superfamily. Like the related protein CD86, this protein is expressed by antigen-presenting cells, and is the ligand for two proteins at the cell surface of T cells, CD28 and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell and induces T-cell proliferation and cytokine production. CTLA-4 binding negatively regulates T-cell activation and diminishes the immune response (1). Blocking the CTLA-4-CD80/CD86 interaction has been shown to enhance T-cell functions in acute lymphoblastomic leukemia (ALL), suggesting that this pathway may be an attractive target for future cancer immunotherapy (2).
1021.39 €
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