anti-FOXO1A (Ab-256)

LF-PA20162

anti-FOXO1A (Ab-256)

Rabbit polyclonal to FOXO1A

751.2 €

LF-PA20163

anti-FOXO1A (Ab-319)

Rabbit polyclonal to FOXO1A

751.2 €

LF-PA20166

anti-FOXO3A (Ab-253)

Rabbit polyclonal to FOXO3A

751.2 €

GB10092

Anti-FOXO3A Rabbit pAb

380 €

GB10092-1

Anti-FOXO3A Rabbit pAb

380 €

ET1604-11

Anti-FOXO3A Antibody [SP0054]

FKHRL1 (forkhead in rhabdomyosarcoma-like 1), also known as FOXO3 (forkheadbox O3) or FOXO3A, is a 673 amino acid transcriptional activator thatbelongs to the FKHR subfamily of forkhead transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 at Threonine 32 and Serine 253. Phosphorylation by Akt1 negatively regulates FKHRL1 by promoting its export from the nucleus. Phosphorylated FKHRL1 associates with 14-3-3 proteins and this complex is retained in the cytoplasm. Growth factor withdrawal stimulates FKHRL1 dephosphorylation and nuclear translocation, leading to FKHR-induced gene-specific transcriptional activation. Within the nucleus, dephosphorylated FKHRL1 triggers apoptosis by inducing the expression of genes that are critical for cell death.

496.5 €