Anti-Cytokeratin 18 Antibody

STJ119983

Anti-Cytokeratin-18 antibody

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

893.4 €

0407-1

Anti-Cytokeratin 18 Antibody

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

433.5 €

34058

Anti-Cytokeratin 18 Antibody

451.5 €

PAab02205

Anti-Cytokeratin 18 antibody

711.2 €

PAab02206

Anti-Cytokeratin 18 antibody

18631 €

STJ92631

Anti-Cytokeratin 18 antibody

Cytokeratin 18 is a protein encoded by the KRT18 gene which is approximately 48 kDa. Cytokeratin 18 is localised to the cytoplasm and nucleus. It is involved in development Slit-Robo signalling, cytoskeletal signalling, ERK signalling, developmental biology and keratinization. It plays a role in the uptake of thrombin-antithrombin complexes by hepatic cells and when phosphorylated it plays a role in filament reorganization. It is also involved in the delivery of mutated CFTR to the plasma membrane and together with KRT8, is involved in interleukin-6-mediated barrier protection. Cytokeratin 18 is expressed in the colon, placenta and liver. Mutations in the KRT18 gene may result in cirrhosis. STJ92631 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cytokeratin 18 protein.

504.6 €