SBE Luciferase Reporter-HEK293 Cell Line

RC1036

SBE Luciferase Reporter-HEK293 Cell Line

The SBE Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the smad binding element (SBE). SMADs are intracellular signaling mediators that transduce extracellular signals from transforming growth factor beta (TGF-beta) ligands to the nucleus where they activate downstream gene transcription. The TGF-beta signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The SBE induction by TGF-beta is shown in Figure 1. 

2947.2 €

ABC-RC0121

Human SBE Luciferase Reporter Cell Line-HEK293

The SBE Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the smad binding element (SBE). SMADs are intracellular signaling mediators that transduce extracellular signals from transforming growth factor beta (TGF-beta) ligands to the nucleus where they activate downstream gene transcription. The TGF-beta signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions.

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MBS668874-1Vial

SMAD-binding element (SBE) Reporter HEK293 Cell Line

2804 €

79754

CSL Reporter - HEK293 Cell line

The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) stably integrated into HEK293 cells. Transfection of this cell line with a Notch expression vector and activation of the Notch pathway leads to expression of luciferase reporter. This cell line is validated with a Notch1DelE expression vector, which is constitutively processed by γ-secretase, leading to the release of NICD and the expression of luciferase.

3562.5 €

ABC-RC0001

GFP Reporter Cell Line-HEK293

GFP Reporter Cell Line-293 stably expresses GFP and blasticidin-resistant genes.Both GFP and blasticidin-resistant genes are introduced into parental 293 cells using lentivirus.

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MBS668863-1Vial

MRE Reporter HEK293 Cell Line

2804 €