RecombinantIL-17A,Mouse
406.5 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 965 - BK0235
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 10μg
Parameters
| Additional information | Interleukin-17A, (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpesvirus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. Recombinant murine IL-17A is a 15-20kDa glycosylated cytokine of 133 amino acid polypeptide chain that plays an important role in antimicrobial and chronic inflammation. IL-17 exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. |
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BK0235
RecombinantIL-17A,Mouse
Measured by its ability to induce IL-1a, IL-4 and IL-6 production by primary mouse splenocytes.
406.5 €
BK0235
RecombinantIL-17A,Mouse
Measured by its ability to induce IL-1a, IL-4 and IL-6 production by primary mouse splenocytes.
132 €
BK0234
RecombinantIL-17A,His,Human
ED50 < 0.3 ng/ml, measured in a bioassay using NHDF cells, corresponding to a specific activity of > 3.3×10ˆ6 units/mg.
406.5 €
BK0109
RecombinantIL-6,Human
ED50 <0.1ng/ml, measured by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells, corresponding to a specific activity of > 1 x 10ˆ7 units/mg.
132 €
BK0240
RecombinantIL-2,Human
ED50 < 2ng/ml, measured in a cell proliferation assay using CTLL-2 cells.
453 €
BK0240
RecombinantIL-2,Human
ED50 < 2ng/ml, measured in a cell proliferation assay using CTLL-2 cells.
156 €
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