Recombinant Mouse MEK1 (EE) (N-GST tag)

40121

Mouse MEK1 (EE), GST-tag

Recombinant mouse MEK1 (S218E, S222E), full length with Serine to Glutamic acid mutations on a.a. 218 and 222 and an N-terminal GST-tag, expressed in E. coli cells.

765 €

MBS4160427-001mg

Recombinant Mouse MEK1 (EE) (N-GST tag)

924.5 €

MBS4160427-5x001mg

Recombinant Mouse MEK1 (EE) (N-GST tag)

3098.38 €

Z600009

Recombinant Mouse EPHA1 (N-GST tag)

 EPHA1 is a member of the Eph family of receptor tyrosine kinases that have been implicated in mediating developmental events, particularly in the nervous system . Receptors in the Eph subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPHA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. EPHA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer . 

671 €

Z600010

Recombinant Mouse EPHA7 (N-GST tag)

EPHA7 is a member of the ephrin receptor subfamily of protein-tyrosine kinases family that have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2-fibronectin types III repeats. EPHA7 mediated signaling act as a physiologic trigger for apoptosis that can alter brain size and shape by regulating the number of neural progenitors . The high expression of EPHA7 protein plays an important role in the malignancy transformation, invasion progression and metastasis of primary hepatocellular carcinoma .

671 €

Z600011

Recombinant Mouse EPHB1 (N-GST tag)

EPHB1 is a member of the Eph family of receptor tyrosine kinases. Ligand-activated EPHB1 forms a signaling complex with Nck, paxillin, and focal adhesion kinase and induces tyrosine phosphorylation of paxillin in a c-Src-dependent manner to promote cell migration . In addition, activated EPHB1 recruits the adaptor proteins Grb2 and p52Shc and promotes p52Shc and c-Src tyrosine phosphorylation as well as MAPK/extracellular signal-regulated kinase (ERK) activation. Expression of dominant-negative c-Src significantly reduced EPHB1-dependent ERK1/2 activation and chemotaxis .

671 €