Raloxifene 6-glucuronide
907.5 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 940 - 574221
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 1.0mg
Parameters
| Additional information | Smiles Code: OC(C=C1)=CC=C1C2=C(C(C3=CC=C(OCCN4CCCCC4)C=C3)=O)C5=CC=C(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O6)C=C5S2 |
|---|
HY-135581
Raloxifene 6-glucuronide
Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[1][2][3].
1274.11 €
HY-135595
6-Raloxifene-β-D-glucopyranoside
6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A[1].
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