Phospho-STAT4-Y693 Rabbit pAb

AP0137

Phospho-STAT4-Y693 Rabbit pAb

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

432.84 €

AP0137-100ul

Phospho-STAT4-Y693 Rabbit pAb

841.2 €

AP0137-200ul

Phospho-STAT4-Y693 Rabbit pAb

1147.2 €

AP0284-50ul

Phospho-STAT2-Y690 Rabbit pAb

627 €

AP0456

Phospho-STAT6-Y641 Rabbit pAb

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

463.51 €

AP0456-100ul

Phospho-STAT6-Y641 Rabbit pAb

841.2 €