Catalog number: 426 - E47R5513
Product Category: Business & Industrial > Science & Laboratory
Size: 100ul
APR02410G
A polyclonal antibody raised in Rabbit that recognizes and binds to Human NFKB1 (Ser893). This antibody is tested and proven to work in the following applications:
CSB-PA258273-
A polyclonal antibody against Phospho-NFKB1 (Ser893). Recognizes Phospho-NFKB1 (Ser893) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF;IHC:1:50-1:100, IF:1:100-1:200
AP0125
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.