![[KO Validated] NFKB1 Rabbit pAb](/_ipx/q_100,fit_outside,s_360x255/images/no-image-product-box.jpg "[KO Validated] NFKB1 Rabbit pAb")
![[KO Validated] NFKB1 Rabbit pAb](/_ipx/_/images/no-image-product-box.jpg "[KO Validated] NFKB1 Rabbit pAb")
[KO Validated] NFKB1 Rabbit pAb
673.27 €
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Catalog number: 806 - A6667-50ul
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 50 ul
![[KO Validated] NFKB1 Rabbit pAb](/images/no-image-product-box.jpg "[KO Validated] NFKB1 Rabbit pAb")
AP0415
Phospho-NFKB1-S893 Rabbit pAb
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.