Phospho-NCF4/p40-phox-T154 Rabbit pAb

AP1193

Phospho-NCF4/p40-phox-T154 Rabbit pAb

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

432.84 €

E45R29224N

Phospho-NCF4/p40-phox-T154 Rabbit pAb

747.75 €

MBS9143900-002mL

Phospho-NCF4/p40-phox-T154 Rabbit pAb

484.62 €

MBS7118612-5x01mg

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1262.38 €

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Phospho-NCF1 (S370) Antibody

376.25 €

MBS7118613-01mg

Phospho-NCF1 (S370) Antibody

427.25 €