Mouse Brain Vascular Pericytes from CD1
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Catalog number: 870 - ABC-TC5503
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 1 vial
ABC-TC5503
Mouse Brain Vascular Pericytes from CD1
Brain Vascular Pericytes (BVP) are perivascular cells that are closely associated with the endothelium of capillaries and other small vessels. BVP, located between endothelial cells and astrocytes in the brain, communicate with other cells by extending long cytoplasmic processes which wrap around the capillaries. BVP participate in a variety of processes including angiogenesis, endothelial cell survival, regulation of capillary blood flow, and establishment and maintenance of the blood-brain barrier. Pericyte dysregulation has been linked to several pathological conditions such as hypertension, diabetic retinopathy, atherosclerosis, multiple sclerosis, Alzheimer’s disease, and tumor angiogenesis. The unique and diverse functions of BVP make them novel candidates for cell therapy in regenerative medicine. Cultured primary mouse BVP (MBVP) are a useful in vitro model for understanding the molecular mechanisms of blood-brain barrier regulation and for studying a wide variety of central nervous system diseases.
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ABC-TC3526
Human Brain Vascular Pericytes
Pericytes are contractile smooth muscle-like cells that cover the abluminal surface of microvessels. They are most abundant on venules and are common on capillaries. The pericytes population is highly variable between different tissues and organs and appears to show functional heterogeneity. Three major functional roles have been ascribed to pericytes associated with central nervous system microvescular-contractility, regulation of endothelial cell activity, and macrophage activity. There is also evidence that pericytes are involved in the transport across the blood-brain barrier and the regulation of vascular permeability. An important role for pericytes in pathology has been indicated in hypertension, diabetic retinopathy, Alzheimerr’s disease, multiple sclerosis and central nervous system tumor formation.HBVP from Gentaur Research Laboratories are isolated from human brain tissue. HBVP are cryopreserved at secondary culture after purification and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HBVP are characterized by immunofluorescent method with antibodies to ?-smooth muscle actin. HBVP are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HBVP are guaranteed to further expand for 15 population doublings in the condition provided by Gentaur Research Laboratories.
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ABC-TC3749
Human Pericytes from Placenta
Pericytes are multipotent mesenchymal-like cells found in association with small blood vessel walls. They are important for angiogenesis, the structural integrity of the microvasculature, and blood flow regulation. However, they can also develop into malignant tumors called hemangiopericytomas.To date, these cells have demonstrated the ability to differentiate into adipocytes, osteoblasts, fibroblasts, smooth muscle cells, and phagocytes (macro -phages).Gentaur offers placenta derived Pericytes produced at Gentaur's cell cul -ture facility from normal human tissues. Shortly after isolation, all Pericytes are cryopreserved at passage 2 (P2) using Gentaur's proprietary, serum-free freezing medium, Cryo-SFM. Each cryo vial contains more than 500,000 viable cells after thawing.Proliferating cell cultures are made from 500,000 cryopreserved cells that have been thawed and cultured for three days at Gentaur.
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ABC-TC3062
BALB/c Mouse Brain Vascular Fibroblasts
BALB/c Mouse Primary Brain Vascular Fibroblasts from Gentaur are isolated from tissue of pathogen-free laboratory mice. Mouse Primary Brain Vascular Fibroblasts are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in Gentaur Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and is delivered frozen.Mouse Primary Brain Vascular Fibroblasts are negative for bacteria, yeast, fungi, and mycoplasma. Cells are tested for expression of marker using the antibody of anti-FSP1/S100A4 by immunofluorescence staining. Cells can be expanded for 2-5 passages at a split ratio of 1:2 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with cell cultures include the assay of cell to cell interaction, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining, flow cytometry or generating cell derivatives for desired research applications.