Human Macrophage scavenger receptor types I and II (MSR1) ELISA Kit

Human Macrophage scavenger receptor types I and II (MSR1) ELISA Kit

1063.5 EUR

1063.5 EUR
In Stock
quantity
Produktdetaljer

Katalognummer: 749 - KTE61522-96T

Produktkategori: Företag och industri > Vetenskap och laboratorium

Leverantör:

AbbkineGentaur

Storlek: 96T

Parameters

Additional informationMSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. 
Storage and shippingStorage: The unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.Shipping:Gel pack with blue ice.