
Katalognummer: 749 - KTE61011-5platesof96wells
Produktkategori: Företag och industri > Vetenskap och laboratorium
Storlek: 5 plates of 96 wells
| Additional information | Peptide YY(3-36) , a Y2R agonist, is released from the gastrointestinal tract postprandially in proportion to the calorie content of a meal. PYY(3-36) also inhibits food intake in mice but not in Y2r- mice, which suggests that the anorectic effect requires the Y2R. Peripheral administration of PYY(3-36) increases c-Fos immunoreactivity in the arcuate nucleus and decreases hypothalamic Npy messenger RNA. Intra-arcuate injection of PYY(3-36) inhibits food intake. PYY(3-36) also inhibits electrical activity of NPY nerve terminals, thus activating adjacent pro-opiomelanocortin (POMC) neurons. In humans, infusion of normal postprandial concentrations of PYY(3-36) significantly decreases appetite and reduces food intake by 33% over 24 h. Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway. |
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| Storage and shipping | All of the components are shipped on ice packs/blue ice. Upon receiving the kit keep it at +4 degrees Celsius for up to 1 year (refer to the label on the box for the exact expiration date). |

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