Anti-PUMA antibody

ER31215

Anti-PUMA Antibody

The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria. Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death. Several studies have shown that PUMA function is affected or absent in cancer cells. Additionally, many human tumors contain p53 mutations, which results in no induction of PUMA, even after DNA damage induced through irradiation or chemotherapy drugs.Other cancers, which exhibit overexpression of antiapotptic Bcl-2 family proteins, counteract and overpower PUMA-induced apoptosis.

433.5 €

E38A2624

Anti-PUMA Antibody

Available in various conjugation types.

487.5 €

MBS175570-01mg

Anti-PUMA antibody

758.75 €

YF-PA25872

anti-Pumilio 2

Mouse polyclonal to Pumilio 2

751.2 €

ET7108-13

Anti-Pumilio 1 Antibody [JG37-75]

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs.

496.5 €

YF-MA17857

Anti-Pumilio 2 (5B6)

Mouse monoclonal to Pumilio 2

803.4 €