ET1606-24

Anti-Phospho-p53 (S392) Antibody [SI17-04]

p53 is a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor that upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 polyubiquitinates p53 for proteasome targeting. p53 can assemble into tetramers in the absence of DNA, fluctuates between latent and active (DNA-binding) conformations, and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) (amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers. Phosphorylation of p53 at residue Thr 155 is mediated by the COP9 signalosome (CSN) and targets p53 to ubiquitin-26S Proteasome-dependent degradation.

501.46 €

MBS8533752-01mL

Phospho-p53 (S392)

579.62 €

MBS8533752-01mLAF405L

Phospho-p53 (S392)

914.43 €

BS9894M

p53 (phospho-S392) Rabbit monoclonal antibody

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

401.98 €

GB114061

Anti-Phospho-p53(S392) Rabbit pAb

383.80 €

3076-100uL

Anti-Phospho-p53 (S392) Rabbit Monoclonal Antibody

730.74 €