Anti-Mouse LPAM-1 Antibody

103-M176

Anti-Mouse LPAM-1 Antibody

The antibody is specific for a combinatorial determinate of integrin α4β7complex. Integrin α4β7 is composed of a 150 kD (α4 or CD49d) and a 130 kD (β7) heterodimer, also known as CD49d/β7 or LPAM-1. Belonging to the Ig superfamily, it is found on the majority of peripheral lymphocytes and subsets of thymocytes and bone marrow cells (including mast cell progenitors). Integrin α4β7 binds its ligands, VCAM-1 (CD106), MAdCAM-1 and fibronectin, and plays an important role in lymphocytes adhesion and the direction of migration of blood lymphocytes to the intestine and associated lymphoid tissues.

748.5 €

MBS697273-0025mg

Anti-Mouse LPAM-1 PE

420.88 €

MBS697273-01mg

Anti-Mouse LPAM-1 PE

548.38 €

ICH1105-50mg

Anti-Mouse LPAM1 In Vivo Antibody - Low Endotoxin (DATK32)

This Rat anti-Mouse LPAM-1 Clone DATK32 antibody recognizes an epitope on Mouse LPAM1 a 130 kDa integrin B7 chain associates with the 150 kDa integrin A4 (CD49d) chain to form LPAM-1, a member of the Ig superfamily

2010 €

ICH1105-5mg

Anti-Mouse LPAM1 In Vivo Antibody - Low Endotoxin (DATK32)

This Rat anti-Mouse LPAM-1 Clone DATK32 antibody recognizes an epitope on Mouse LPAM1 a 130 kDa integrin B7 chain associates with the 150 kDa integrin A4 (CD49d) chain to form LPAM-1, a member of the Ig superfamily

380 €

103-M435

Anti-Mouse MD-1 Antibody

MD1 is a secreted glycoprotein that was originally identified as a v-myb-regulated gene from avian myeloleukemia virus-transformed chicken myeloblasts. The mouse homologue of chicken MD1 (also known as lymphocyte antigen 86) was subsequently discovered as a molecule that is associated with RP105, a type I transmembrane glycoprotein with extracellular leucine rich repeats (LRR) typically found in Toll-like receptor (TLR) family members. However, RP105 has a short cytoplasmic tail and lacks the TollIL1 R (TIR) domain that defines the IL1 R/TLR superfamily. RP105 plays an important role in B-cell activation by bacterial lipopolysaccharide (LPS). It is expressed primarily on mature B cells, dendritic cells and macrophages. Mouse MD1 cDNA encodes a 162 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and two potential Nlinked glycosylation sites. It shares 40% and 66% aa sequence identity with chicken and human MD1 respectively. MD1 is mainly expressed in spleen, and also detectable in liver, brain, thymus, and kidney. MD1 is required for efficient RP105 cell surface expression and function. Cell surface RP105/MD1 complex, in conjunction with TLR4, mediates the innate immune response to LPS in Bcells. Activation of the RP105 complex has been shown to protect against apoptosis, induce Bcell proliferation and upregulate B7.2, a costimulatory molecule. Since MD1 is also expressed in liver and brain where RP105 is absent, it has been speculated that MD1 can also be associated with other LRR-containing molecules, or have additional functions outside the immune system.

748.5 €