Anti-HER2/ErbB2 Antibody
2590.93 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 544 - MBS9231151-5x01mL
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 5x0.1mL
Parameters
| Storage and shipping | Store at -20 degree C. Stable for 12 months from date of receipt |
|---|
A00539
Anti-HER3 ERBB3 Antibody
Boster Bio Anti-HER3 ERBB3 Antibody (Catalog # A00539). Tested in ELISA, IP, WB applications. This antibody reacts with Human.
991.5 €
ER0106
Anti-HER2 / ErbB2 Antibody
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approx. 30% of breast cancer patients. Over-expression is also known to occur in ovarian, stomach, and aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma. The expression of HER2 is regulated by signaling through estrogen receptors. Normally, estradiol and tamoxifen acting through the estrogen receptor down-regulate the expression of HER2. However, when the ratio of the coactivator AIB-3 exceeds that of the corepressor PAX2, the expression of HER2 is upregulated in the presence of tamoxifen, leading to tamoxifen-resistant breast cancer.
433.5 €
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